Academics

Bio

Dr. Manasi Mishra is working as Associate Professor in Department of Biosciences & Technology, MIT-World Peace University. She has been actively working in the area of plant immunity proteins and peptides involved in defense against insect pest infestation and those with relevance in the context of crop improvement. Her research has been focused on structure-function correlation of diverse plant defense proteins, molecular diversity and their functional significance. She is also working extensively towards understanding the defense peptides distribution within individual plants and their tissues, factors influencing their expression, gene architecture, post-translational mechanisms, bioactivities and designing synthetic peptides directed towards therapeutic molecular targets.

Her research Interests include Plant immunity proteins and peptides, Plant bioactive molecules, Botanical therapeutics, Protein engineering, Molecular diversity and evolution. She is a recipient of short-term DAAD fellowship and conducted collaborative research at EMBL Hamburg, Germany. She is also the recipient of DST-INSPIRE Faculty Fellowship award from Department of Science & Technology and Indo-Australian Career Boosting Gold Fellowship from Department of Biotechnology, Govt. of India.

Subjects Taught

Biology for engineers, Synthetic Biology and Biologics production; Genomics and Genetic engineering, Translational approaches in Biotechnology

Research Interests

Plant defense proteins and peptides, Plant bioactive molecules, Botanical therapeutics, Molecular diversity and evolution

Research Papers

Mishra M, Singh V, Tellis MB, Joshi RS, Singh S (2021) Repurposing the McoTI-II rigid molecular scaffold in to inhibitor of ‘papain superfamily’ cysteine proteases. Pharmaceuticals 14, 7: 1-17.

Mishra M, Singh V, Tellis MB, Joshi RS, Pandey KC, Singh S (2020) Cyclic peptide engineered from phytocystatin inhibitory hairpin loop as an effective modulator of falcipains and potent anti-malarial. Journal of Biomolecular Structure and Dynamics (https://doi.org/10.1080/07391102.2020.1848629).

Mishra M (2020) Evolutionary aspects of the structural convergence and functional diversification of Kunitz-domain inhibitors. Journal of Molecular Evolution 88(7): 537-548.

Mishra M, Singh V, Singh S (2019) Structural insights in to key Plasmodium proteases as therapeutic drug targets. Frontiers in Microbiology 10:394.

Mishra M, Mahajan N, Tamhane VA, Kulkarni MJ, Baldwin IT, Gupta VS and Giri AP (2012) Stress inducible proteinase inhibitor diversity in Capsicum annuum. BMC Plant Biology 12:217.

Mishra M, Tamhane VA, Khandelwal N, Kulkarni MJ, Gupta VS and Giri AP (2010) Interaction of recombinant CanPIs with Helicoverpa armigera gut proteases reveals their processing patterns, stability and efficiency. Proteomics 10(15):2845-2857.

Books Published

Book Chapter:Gurjar G, Mishra M, Kotkar H, Upasani M, Pradeep Kumar, Tamhane V, Kadoo N, Giri A and Gupta V (2011). Book Chapter: Major biotic stresses of chickpea and strategies for their control. Pests and Pathogens: Management Strategies. BS Publications, CRC Press ISBN: 978-0-415-66576-6.

Patents

1. Ashok P. Giri, Rakesh S. Joshi, Vaijayanti A Tamhane, Manasi Mishra, Vidya S. Gupta, Anirban Ghosh, Uddhavesh Sonavane, Rajendra Joshi "Effective management of Helicoverpa armigera involves cloning of inhibitory repeat domain 9 in Pichia pastoris in specific vector, feeding inhibitory repeat domain 9 proteins to Helicoverpa armigera and calculating specific growth parameters”. Patent Number: WO2013102937-A2; IN201200035-I1; WO2013102937-A3 US patent: 9,357,777

Teaching Experience

6 years

Research Experience

11 years

Linkedin Profile Link

https://www.linkedin.com/in/manasi-mishra-89549452/

ORCID ID Link

https://orcid.org/0000-0002-3304-9105