Academics

Bio

Dr. Bishnudeo Roy, an Assistant Professor at the Department of Biosceinces and Technology, MIT-WPU, Pune, holds research experience of more than sixteen years in the area of B cell immunology and immunemodulation by various biomolecules. After having obtained a Ph.D. degree in Immunology from Hannover Medical School, Hannover, Germany, in 2007, he carried his first and second postdoctoral reasearch at Helmholtz Centre for Infection Research, Braunschweig, Germany, and Oslo Oniversity Hospital, Oslo, Norway, respectively. His doctoral and postdoctoral work focused on characterization of antibody profile of various B cell populations from mice and and humans using single cell high throughput seqeuncing. Protocol for the high throughput isolation and sequencing of paired heavy and light chain genes of individual antigen-specific plasma cells established by him was pivotal in characterizing the auto-reactive antibody repertoire genes from a few thousand B cell clones of celiac disease (an autoimmune condition) patients. Recent research publications authored/co-authored by him encompass: 1. assessment of immunization efficiency of two COVID-19 vaccinces manufactured in India 2. impact of aldosterone on macrophage survival and activation in hyperglycemic conditions 3. quantitative assessment of SARS-CoV-2 load in wastewater of Pune and 4. identification and characterization of L-asparaginase producing human commensal bacteria that can be used for anti-cancer therapy. He has published 16 research/review articles and his current h- and i-index is 9.

Subjects Taught

Immunology and Immunotechnology, Molecular Biology, Cell Biology, Animal Tissue Culture, Animal Biotechnology, Molecular Diagnostics and Clinical Research, Practicals in Biochemistry

Research Interests

Antibody profiling using single cell high throughput sequencing, Immunomodulation by biomolecules, Generation and characterization of monoclonal antiobodies

Research Papers

Zambre S, Katarmal P, Pawar S, Dawkhar S, Iyer P, Rajput V, Kadam P, Bhalerao U, Tupekar M, Shah P, Karmodiya K, Dharne M, Roy B, Koraktar S. Wastewater surveillance of severe acute respiratory syndrome coronavirus-2 in open drains of two Indian megacities captures evolutionary lineage transitions: a zonation approach. Environ Sci Pollut Res Int. 2024 Aug;31(37):49670-49681. doi: 10.1007/s11356-024-34448-7.

Sapkota H, Singhania U, Jadhav S, Pathan EK, Roy B. Isolation, Identification, and Characterization of L-asparaginase-Producing Human Commensal Bacterial Strains: A Promising Next-Gen Probiotics. Appl Biochem Biotechnol. 2024 Aug 7. doi: 10.1007/s12010-024-05002-5.

Apte M, Zambre S, Pisar P, Roy B, Tupe R. Decoding the role of aldosterone in glycation-induced diabetic complications. Biochem Biophys Res Commun. 2024 Aug 20;721:150107. doi: 10.1016/j.bbrc.2024.150107.

Asokan MS, Joan RF, Babji S, Dayma G, Nadukkandy P, Subrahmanyam V, Pandey A, Malagi G, Arya P, Mahajan V, Bhavikatti J, Pawar K, Thorat A, Shah P, Goud RB, Roy B, ……Mayor S, et al. Immunogenicity of SARS-CoV-2 vaccines BBV152 (COVAXIN®) and ChAdOx1 nCoV-19 (COVISHIELD™) in seronegative and seropositive individuals in India: a multicentre, nonrandomised observational study. Lancet Reg Health Southeast Asia. 2024 Feb 27;22:100361. doi: 10.1016/j.lansea.2024.100361.

Zambre S, Bangar N, Mistry A, Katarmal P, Khan MS, Ahmed I, Tupe R, Roy B. Aldosterone, Methylglyoxal, and Glycated Albumin Interaction with Macrophage Cells Affects Their Viability, Activation, and Differentiation. ACS Omega. 2024 Feb 27;9(10):11848-11859. doi: 10.1021/acsomega.3c09420.

Sisodiya S, Kasherwal V, Khan A, Roy B, Goel A, Kumar S, Arif N, Tanwar P, Hussain S. Liquid Biopsies: Emerging role and clinical applications in solid tumours. Transl Oncol. 2023 Sep;35:101716. doi: 10.1016/j.tranon.2023.101716.7.

Iversen R, Roy B, Stamnaes J, Høydahl LS, Hnida K, Neumann RS, Korponay-Szabó IR, Lundin KEA, Sollid LM. Efficient T cell-B cell collaboration guides autoantibody epitope bias and onset of celiac disease. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15134-15139. doi: 10.1073/pnas.1901561116.

Brennecke AM, Düber S, Roy B, Thomsen I, Garbe AI, Klawonn F, Pabst O, Kretschmer K, Weiss S. Induced B Cell Development in Adult Mice. Front Immunol. 2018 Oct 31;9:2483. doi: 10.3389/fimmu.2018.02483.

Blume J, Ziętara N, Witzlau K, Liu Y, Sanchez OO, Puchałka J, Winter SJ, Kunze-Schumacher H, Saran N, Düber S, Roy B, Weiss S, Klein C, Wurst W, Łyszkiewicz M, Krueger A. miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1. Eur J Immunol. 2019 Jan;49(1):121-132. doi: 10.1002/eji.201847660. Epub 2018 Oct 22.

Roy B, Neumann RS, Snir O, Iversen R, Sandve GK, Lundin KEA, Sollid LM. High-Throughput Single-Cell Analysis of B Cell Receptor Usage among Autoantigen-Specific Plasma Cells in Celiac Disease. J Immunol. 2017 Jul 15;199(2):782-791. doi: 10.4049/jimmunol.1700169. Epub 2017 Jun 9.

Suwandi A, Bargen I, Roy B, Pils MC, Krey M, Zur Lage S, Basler T, Rohde M, Falk CS, Hornef MW, Goethe R, Weiss S. Experimental colitis is exacerbated by concomitant infection with Mycobacterium avium ssp. paratuberculosis. Inflamm Bowel Dis. 2014 Nov;20(11):1962-71. doi: 10.1097/MIB.0000000000000157.

Roy B, Brennecke AM, Agarwal S, Krey M, Düber S, Weiss S. An intrinsic propensity of murine peritoneal B1b cells to switch to IgA in presence of TGF-β and retinoic acid. PLoS One. 2013 Dec 6;8(12):e82121. doi: 10.1371/journal.pone.0082121.

Teaching Experience

6 Yrs

Research Experience

16 Yrs

Linkedin Profile Link

linkedin.com/in/bishnudeo-roy-a26b4a60

Scopus ID Link

https://www.scopus.com/authid/detail.uri?authorId=26026492200

ORCID ID Link

https://orcid.org/0000-0002-7339-9556

Researcher ID Link

https://www.webofscience.com/wos/author/record/Q-2629-2018

Vidwan Profile Link

https://vidwan.inflibnet.ac.in/profile/296627