Pharmaceutics is the branch of pharmacy that deals with the process/es of converting a new chemical entity (NCE) into a drug product for safety and efficacy of patients. It is also known as the science of design of dosage forms. Globally, India ranks 3rd in terms of manufacturing drug products by volume. Indian pharmaceutical industries are not only fulfilling the country’s demands, but they are also exporting medicines to nearly 220 countries. Pharmaceutics deals with the preformulation studies, formulation development, unit-operations, compounding of extemporaneous preparations, stability, novel drug delivery systems such as transdermal patches, microspheres, nanoformulations, liposomes etc. The pharmacokinetic and pharmacodynamic aspects of the active and the dosage form are determined to conclude the dosage regimen. Recently Pharmaceutics focuses on Regulatory Affairs which ensures the quality of the drug.
All the laboratories of Pharmaceutics department namely, Galen’s Pharmaceutics Laboratory, Wren’s Pharmaceutics Laboratory & Sterile Product Preparation area, Wurster’s Pilot Plant (Machine room), Research Laboratory -M. Pharm. Pharmaceutics, Research Laboratory- Cell biology are well ventilated, spacious AND STATE of art. The laboratories contain the equipment needed for preformulation, formulation design, preparation of conventional dosage forms and novel drug delivery systems. To name the few equipment, Galen’s Laboratory, Wren’s Laboratory, Wurster’s Pilot Plant have dissolution test apparatus, aseptic filling and sealing area, membrane filtration unit, tablet compression machine, stability chamber, tablet coating machine. M. Pharm. Research Laboratory focuses on designing and evaluation of novel drug delivery systems and has probe sonicator, high pressure homogenizer, moisture balance, Brookfield viscometer. Research Laboratory- Cell biology is equipped with fluorescence microscope, Differential Scanning Colorimeter.
The term ‘Pharmacology’ is derived from Greek words Pharmakon (drug) and logos (study). Thus, Pharmacology involves the study of the actions of drugs and chemicals on cells, tissues organs and the whole body. It includes finding out how drugs produce beneficial and adverse effects, with the aim of improving the way to give greater benefit in the treatment of disease.
Goodman’s Anatomy Physiology and Pharmacology laboratory is spacious and ventilated laboratory located on second floor of the building college. It is equipped with various equipment’s needed for in-vitro and in-vivo experimental pharmacology. Clinical chemistry analyser, plate reader, high speed refrigerated centrifuge, tissue homogenizer, actophotometer, electro-convulsiometer, Eddy’s hot plate, organ bath and Sherrington’s rotating drum, rota rod, tail-flick apparatus are available in the laboratory. The laboratory also has departmental library maintained with various reference books of Pharmacology.
Dale’s Human Anatomy, Physiology laboratory is located on the fourth floor of building. It is well equipped with necessary equipments, charts and models required for understanding the anatomy and physiology of human body. Equipments such as Hutchinson spirometer, pole climbing apparatus, Morris water maze, open field apparatus, Persolt’s apparatus, radial arm maze, sphygmomanometer, glucometer, hemoglobinometer, hemocyctometer are available in the laboratory.
Animal house facility is located on the second floor of the building for rodents. This facility has been recognized by Committee for the Purpose of Control and Supervision of Experiments on Animals CPSCEA, Govt. of India, New Delhi (Approval No. 941/Po/c/06/CPCSEA). It is utilized for animal related experimentation in the department.
PHARMACEUTICAL CHEMISTRY LABORATORY :
Pharmaceutical Chemistry is one of the core subject in pharmaceutical sciences. Pharmaceutical / Medicinal chemistry involves the basic process of drug design and discovery. The principles of the subject are applicable to all the branches of pharmaceutical sciences.
Pharmaceutical Chemistry is the study of the molecular and mechanistic aspects of pharmaceuticals. The discipline emphasizes the chemistry of drug design and development, drug action, drug transport, drug delivery, and targeting. The development of new pharmaceuticals is critically dependent on a molecular-level understanding of biological processes and mechanisms of drug action.
Burger Pharmaceutical Chemistry Laboratory is located on Ground floor of the building and well equipped for conducting research in pharmaceutical Chemistry and drug designing. Scientific microwave synthesizer, parallel synthesizer, synthetic reactor, rotary evaporator, vacuum oven, suction pump, Melting point apparatus, fume cupboard, hot air oven, mechanical and magnetic stirrers, electronic water bath etc. are available in the laboratory.
Domagk’s Medicinal Chemistry Laboratory is located on the ground floor of the building. It is equipped with the necessary instruments and equipments required to carry out Experimental work in medicinal chemistry and research work related to synthetic part of drug design. Fuming cupboard, hot air oven, UV chamber, distillation unit, vacuum pump are available in laboratory.
Vogel’s Pharmaceutical Chemistry Laboratory is located on ground floor of the pharmacy building. The lab is equipped with Fuming Cupboard, Vacuum Pump for filtration, Melting point apparatus, hot air oven, hot plates, heating mantle etc.
PHARMACEUTICAL QUALITY ASSURANCE LABORATORY
Quality Assurance is dynamic, versatile and most inclusive branch in the Pharmaceutical and health care field which offers wide carrier opportunities to the aspirants. It is the pervasive and indispensable component of any pharmaceutical and health care organization. Person planning carrier in QA needs to imbibe itself with technical and other skills so to become immediately indispensible entity of the organization. The pharmaceutical industry is the most regulated among all other industries. Each country has well established drug regulatory authorities controlling all regulatory aspects quality Assurance perform most deserved function liaison among all the functions of an organisation (viz. research, manufacturing, transport, sales, safe disposal, etc.) dealing with pharmaceuticals, medical devices and diagnostics and other health care needs such as specialized foods articles and dietary supplements and many more.
Quality Assurance Research Laboratory is well equipped and well organised research laboratory. PG and Ph. D. Scholars are working on research projects. It is located on third floor of the building and provides and contains the necessary equipment needed to conduct multidisciplinary research. Currently available instruments are HPLC, Flash chromatography, FTIR, UV VIS spectrophotometry, hot air oven, double distillation plant etc. Regular practical’s of M. Pharm.- Pharmaceutical Quality Assurance PG program as per WUP curriculum are conducted in the lab.
PHARMACOGNOSY AND PHYTOCHEMISTRY LABORATORY
“Pharmacognosy” derives from two Greek words, “pharmakon”or drug, and “gnosis” or knowledge. Thus, Pharmacognosy (chemistry and biology of natural products) is the study of natural substances found in terrestrial and marine organisms (plants, animals, or microbes). Pharmacognosy has undergone significant change in recent years and today represents a highly interdisciplinary science which is one of five major areas of pharmaceutical education.
Research in Pharmacognosy
Despite convincing progress in Synthetic Chemistry, plants are the most important sources for preventive and curative medical preparations. WHO has estimated that at least 80% of all the global inhabitants rely on curative medical systems of medicine for their primary health needs and these systems are largely plant based. Research in Pharmacognosy is important because it leads new types of therapeutic moiety; increased understanding of the pharmacological, ecological and biochemical roles of molecules produced by nature; information on herbal medicines; and new methods for the analysis of drugs and herbal formulations. Research in the department of Pharmacognosy focused on analysis of medicinal plants including isolation, purification, identification and structure determination of bioactive substances from plant sources. The major research interests of department include:
Extraction, isolation and purification of medicinal plants.
Pharmacognostical and phytochemical studies of some selected medicinal plants.
Studies on herbal cosmetics.
Development of stable herbal formulation/Ayurvedic preparation.
Standardization of traditional formulations
Plant tissue culture.
CharakPharmacognosy and Phytochemistry laboratory is well equipped and ventilated and located on first floor of the building and provides and contains the necessary equipment needed to conduct research in pharmacognosy. Motic microscope, Muffle furnace, hot air oven, extraction assemblies, soxhlet apparatus, columns, TLC chambers, compound microscopes etc. are available in the laboratories.